Missouri Route 66 Itineraries & Routes

Missouri’s Route 66 is a vibrant tapestry woven from neon signs, quirky roadside attractions, and a rich history that whispers tales of outlaws, pioneers, and the American dream. It’s a road trip through time, winding through bustling cities, charming towns, and breathtaking landscapes. Whether you’re a seasoned Route 66 enthusiast or a wide-eyed newbie, Missouri’s 317 miles of the Mother Road promise an unforgettable odyssey. Having the perfect Missouri Route 66 itineraries and routes will help you cruise your way through the “Show Me State” on this stretch of your journey.

The first thing you need to do is decide how much time you have. Missouris Route 66 is about 317 miles long, so you could do it in a day if you’re really pressed for time. But to truly experience the magic of the Mother Road, you’ll want to take your time. Two or three days is a good starting point, but you could easily spend a week or more exploring all that Missouri has to offer.

Once you know how much time you have, you can start planning your Missouri Route 66 itinerary. There are many different ways to do this, and many cities and attractions to explore. Browse our Missouri Route 66 itineraries, city guides, routes, attraction profiles, and articles below to plan your perfect road trip.

Missouri Route 66 Itineraries & Routes

Whether you’re traversing the entire state or just taking a day trip between cities and traveling east to west or west to east, explore these Missouri Route 66 itineraries & routes to plan your perfect journey on The Mother Road.

Missouri Route 66 City Guides

Missouri is home to a diverse range of cities and towns each with its own character and charm. Take a deep dive into some of the most popular places to pull over with these Missouri Route 66 City Guides. Find the best attractions, hotels and motels, restaurants, and more in every city on Missouri Route 66.

Latest Missouri Attractions

Build your Missouri Route 66 itineraries with all the quintessential attractions you’ll find at every turn of the road.

Plan Your Missouri Route 66 Road Trip

Need more inspiration? Peruse these Missouri Route 66 road trip planning guides.

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